The refining of clinico-pathologic correlation using dermoscopy by Scope et al in the area of dermatology has led to “a plea for a combined diagnostic approach of histopathologic and dermoscopic evaluation of melanocytic lesions”. Integration between dermoscopy and histology was only effective in a limited number of scientific works despite its promising premise. We propose that a sub-millimetre skin biopsy device known as the Microbiopsy for minimally invasive and suture-free skin sampling for molecular diagnosis be used for this purpose. To this end we are integrating microbiopsy based sampling into dermoscopy to enable dermoscopy guided microbiopsy for molecular diagnosis. We will discuss our recent advances in microbiopsy technology and the future of dermoscopy-guided microbiopsy.