Poster Presentation Australasian Society for Dermatological Research Annual Scientific Meeting 2017

Skin cancer incidence and risk factors in Australian heart and lung transplant recipients: A single-centre retrospective study (#34)

Nicholas F De Rosa 1 , Vanessa Paddon , Stephen Kerr 2 , Allan Glanville 3 , Kurosh Parsi
  1. Department of Dermatology, St Vincent's Hospital, Sydney, NSW, Australia
  2. The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
  3. Department of Thoracic Medicine, St Vincent's Hospital, Sydney, NSW, Australia

Background:

Skin cancer is recognised as a major cause of morbidity and mortality in immunosuppressed solid organ transplant recipients (SOTR).1 There is limited research on the incidence of cutaneous malignancy in Australian SOTR and scarce data involving heart and lung transplant recipients (HLTR). HLTR are subject to a more profound immunosuppression than other SOTR, which may lead to an increased incidence of cutaneous malignancy.2

Objectives:

To examine the incidence and risk factors for skin cancer in the heart and lung transplant population at St. Vincent's Hospital Sydney.

Methods:

Consenting participants were recruited in the dermatology outpatient clinic over 10 months. Information on participant characteristics and risk factors were gathered from an administered questionnaire and review of case notes. Previous skin cancer diagnoses were determined retrospectively from hospital histopathology results. Risk factors examined included time since transplant, organ transplanted, end-organ disease, immunosuppressive medication, skin phenotype, previous sun exposure, allograft rejection, family history of skin cancer, voriconazole use, acitretin use, sirolimus use, smoking history, and cancer history. The probability of developing skin cancer was assessed using survival analysis techniques.

Results:

Preliminary results reveal 801 histopathologically diagnosed cutaneous malignancies in 57 of 94 (61% of) participants, including 584 squamous cell carcinomas (SCC) and 206 basal cell carcinomas (BCC). The SCC:BCC ratio was 2.8:1, which is an approximate reversal of the ratio found in the general population.1 Using Kaplan-Meier analysis of this preliminary data, the probability of any non-melanoma skin cancer (NMSC) post-transplant was 17% at 2 years, 42% at 5 years and 64% at 10 years. There was a trend towards a higher number of NMSC in lung transplant recipients compared to heart.

  1. 1. STOFF, B., SALISBURY, C., PARKER, D. & O'REILLY ZWALD, F. 2010. Dermatopathology of skin cancer in solid organ transplant recipients. Transplantation Reviews, 24, 172-89.
  2. 2. RASHTAK, S., DIERKHISING, R. A., KREMERS, W. K., PETERS, S. G., CASSIVI, S. D. & OTLEY, C. C. 2015. Incidence and risk factors for skin cancer following lung transplantation. Journal of the American Academy of Dermatology, 72, 92-8.
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